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• Babies and children feature heavily in this August issue of

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  Babies and children feature heavily in this August issue of , as well they should at a time when unfinished agendas are top of the agenda. In its 2014 report on the , released on July 7, the UN described the under-5 mortality goal as “slipping away from achievement by 2015”. The research and opinion

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• br Voltage gated sodium channels are essential for modulatin

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  Voltage-gated sodium mtor inhibitor are essential for modulating the amplitude and upstroke velocity of the cardiac action potential, which are parameters that are important determinants of impulse propagation and conduction velocity through the myocardium. Functional analyses using patch-clamp t

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  Martyn Plummer and colleagues (September, 2016) analyse the global burden of cancers attributable to infections in 2012. Despite the relatively low attributable proportion compared with other infectious agents, liver flukes, including and , were estimated to have caused 1300 new cases of cholangi

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  Macrophages in bone metastasis – main outstanding questions: Conflict of interest statement Acknowledgements IV was supported by a generous grant from Weston Park Hospital Cancer Charity, Sheffield, UK. Introduction In recent years there has been increasing interest in the role of bone-ta

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  Our analysis also showed that there were no meaningful lipid changes with anastrozle, as a surrogate for cardiovascular health. This is in keeping with the TEAM Japan [17], TEAM Greek [18] sub-studies and the SABRE trial [19], which showed that AIs have no detrimental effects on lipid parameters. Th

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  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

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  El impulso universalista de Sur afectó de distintas formas su política editorial. En general transitó los marcos de los ideales de Victoria Ocampo, quien además de directora era mecenas del proyecto, y los de José Bianco, que desempeñó por más de 20 años las labores de la secretaría de redacción. L

• The mechanism leading to the gelatinous

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  The mechanism leading to the gelatinous transformation may involve inhibition of tyrosine kinase activity by tyrosine kinase inhibitors (TKI) leading to blockage of downstream signal pathways, affecting extracellular matrix deposition, adipocyte differentiation and angiogenesis. Moreover, the catabo

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