• In vivo study showed that the CYP A activity was

  2020-08-26

  

  In vivo study showed that the CYP3A activity was increased, when morroniside (10, 30 and 90 mg/kg, i.g.) was daily for seven consecutive days. Further, RT-PCR analysis showed that the induction of mRNA histone acetyltransferase by morroniside (10, 30 and 90 mg/kg, i.g.) was 1.13-, 1.43- and 1.79-fo

• br Activatable optical imaging probes

  2020-08-26

  

  Activatable optical imaging probes Optical fluorescence imaging, which directly detects photons emitted from fluorescent probes, has become as a powerful analytical method to study biological processes both in vitro and in vivo. It is characterized by high sensitivity, is free of radioactive irra

• Enolase as a plasminogen receptor

  2020-08-26

  

  Enolase, as a plasminogen receptor and activator localized on the surface of several helminths, can interact with the host fibrinolytic system (Yang et al., 2010, Du et al., 2009, de la Torre-Escudero et al., 2010). The enzyme is also one of excretory/secretory (ES) products in some helminths, such

• Proinflammatory cytokines induce ER stress in many mammalian

  2020-08-26

  

  Proinflammatory cytokines induce ER stress in many mammalian cell systems.32, 33, 34 Our results demonstrate that these cytokines also trigger ER stress in trophoblast JEG-3 cells. However, the severity of stress is likely low grade because only the PERK-EIF2A arm of the UPRER pathway was activated.

• br Results br Discussion The process by which MBCs

  2020-08-26

  

  Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor ABT 702 dihydrochloride within the GC. The identification here of a distinct subset of GC B cell

• In contrast to SQLE HMGCR

  2020-08-26

  

  In contrast to SQLE, HMGCR could be efficiently degraded in mt t lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recently repo

• br Abbreviations br Acknowledgements br Introduction Dopamin

  2020-08-26

  

  Abbreviations Acknowledgements Introduction Dopamine β-hydroxylase (DbH) is the enzyme catalysing the conversion of dopamine to norepinephrine, two important neurotransmitters involved in the central nervous system [1]. This enzyme has been isolated from bovine chromaffin granules as a tetr

• Role of ROS signaling in

  2020-08-24

  

  Role of ROS signaling in regulating cell death pathways has been well established. Involvement of CLIC1 in ROS production has been studied earlier. It was observed that macrophages from clic1 mice showed ~30% decrease in cellular ROS generation which effects macrophage function (Jiang et al., 2012).

• All these results indicate that cleaving embryos possess a r

  2020-08-24

  

  All these results indicate that cleaving embryos possess a regulative mechanism, sensing the number of inner Bromfenac Sodium and controlling the proportion of conservative and differentiative divisions of blastomeres. The current observations agree with the results from other laboratories and our p

• Primary renal PNET was first reported by Seemayer et

  2020-08-24

  

  Primary renal PNET was first reported by Seemayer et al in 1975. The possible etiology of rPNET is based on the theory of neural cell intussusception in the kidney during development that initiates the tumorigenesis. rPNET most commonly affects young adults, with a mean age of 30.4 years and male pr

• Considering these reports and with the aim of

  2020-08-24

  

  Considering these reports, and with the aim of further investigating the mechanism by which the cAMP-Epac/PKA pathway activates eNOS, we have performed imaging experiments evaluating the effect of drugs that increase cAMP or modify its signalling pathways (PKA or Epac activators and inhibitors) on b

• Covalent inhibitors are well suited for targeting the E

  2020-08-24

  

  Covalent inhibitors are well suited for targeting the E1 Genistein of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring compounds to be stable in circu

• ion channels br E intracellular localization br Regulation o

  2020-08-24

  

  E1 intracellular localization Regulation of E1 by other post-translational modifications Concluding remarks Acknowledgments We apologize to those whose work was not included because of space considerations or whose papers were unintentionally omitted. We thank Dr Peter Bullock (Tufts Uni

• The mesolimbic dopamine system is believed to be highly

  2020-08-24

  

  The mesolimbic dopamine system is believed to be highly important for evaluating environmental stimuli in order to generate an adaptive behavioral response. Thus, not surprisingly these functions appear to have been highly conserved across the vertebrate subphylum. Even though teleost fish lack midb

• 15 We next focused our design building into the ribose bindi

  2020-08-24

  

  We next focused our design building into the ribose binding site, which had not been yet utilized in this effort. Compounds bearing a series of five-membered aromatic heterocycles (compound , ) showed reduced inhibition of the Gram-positive isozymes compared with compound , but a 20-fold improved po

15743 records 797/1050 page Previous Next First page 上5页 796797798799800 下5页 Last page