• br DGAT Deficient Mice are Resistant to Obesity To

  2020-08-04

  

  DGAT-Deficient Mice are Resistant to Obesity To address questions concerning the function of DGAT, we inactivated its gene in mice (Smith et al. 2000). Surprisingly, DGAT knockout (Dgat−/−) mice, although deficient in DGAT activity, were viable and capable of synthesizing triglycerides, as eviden

• Hypermethylation of CpG islands in cancer exhibits heterogen

  2020-08-03

  

  Hypermethylation of CpG islands in cancer exhibits heterogeneity both within the same tumor types and among different tumor types.36, 37 Methylated CpG islands are often, but not always, associated with transcriptional silencing.38, 39 A recent study suggested that aberrant methylation of CpG island

• br Acknowledgements This work was supported

  2020-08-03

  

  Acknowledgements This work was supported by the National Natural Science Foundation of China (31572039), the National Program on Key Basic Research Projects (973 Program, 2013CB127600) and China Postdoctoral Science Foundation (2016M601946). Introduction Parkinson\'s disease (PD) is a neurolo

• The single amino acid change at position

  2020-08-03

  

  The single amino Tn5 DNA Library for 50 ng DNA sale change at position 331 in the P. larvae enolase produced a different affinity and turnover rate for 2-PGA. The enolase found within strains of Plp demonstrated an affinity for substrate (i.e., Km) 2.8 times, and an enzymatic efficiency 1.6 times,

• We not only found that the

  2020-08-03

  

  We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is

• It has been suggested that

  2020-08-03

  

  It has been suggested, that NHEJ is the initial default pathway for DSB repair and, when NHEJ fails, HR may take over [56], [57]. Thus, the affinity of DNA-PKcs for the crossover region of Holliday junctions could anticipate an unexpected backup mechanism for the down regulation of improper recombin

• br Background of chloride channels Anion selective channels

  2020-07-31

  

  Background of chloride channels Anion selective kainic acid have been classified into several group based on functional properties such as voltage dependence, single conductance, selectivity, sensitivity to blockers, kinetics, molecular structures and subcellular localization. Electrophysiologic

• Genetic findings in ephrinB EphB RASA

  2020-07-31

  

  Genetic findings in ephrinB2-EphB4-RASA1 signaling axis genes also provided insights into potential diagnostic and therapeutic strategies for cerebrovascular disorders. Given the incomplete penetrance and variable expressivity, prenatal genetic screens in pregnant women with a family history of cuta

• We also extended our observations

  2020-07-31

  

  We also extended our observations with Ube2E1 to other members of Ube2E class of E2s to show that self-ubiquitination-mediated activity attenuation is preserved across the Ube2E family. Sequence analysis revealed that this guggulsterone preservation is a consequence of perfectly conserved lysines in

• A significant issue that has

  2020-07-31

  

  A significant issue that has limited the biochemical characterization of the E1 helicase to only a few PV types has been the difficulty in expressing and purifying large quantities of the protein in a recombinant form that can support cell-free DNA replication. This is in part due to the fact that E

• Human UBA has two isoforms each including the above mentione

  2020-07-30

  

  Human UBA5 has two isoforms, each including the above-mentioned three regions: the adenylation domain, UIS and UFC1-binding sequence [1], [33]. However, only one has an extension of 56 Erastin N-terminal to the adenylation domain (Fig. 1a). Previously, we and others have shown that the short isofor

• Protection of DNA is a

  2020-07-30

  

  Protection of DNA is a cancer preventive mechanism; both oxidative and alkylating damage to colonocytes are known effects of dietary carcinogens. Concerning the DNA protection experiments, two different DNA damaging agents, an oxidant (H2O2) and alkylating (MMS) agent, were used. Hydrogen peroxide i

• Prostate cancer bone metastases result in mixed heterogeneou

  2020-07-30

  

  Prostate cancer bone metastases result in mixed, heterogeneous osteoblastic and osteolytic lesions. Osteoblastic lesions are characterized by excess deposition of new bone, whereas osteolytic lesions are characterized by the destruction of bone. These two types of PCa bone metastases all cause distu

• As theta was reported to regulate autophagy by

  2020-07-30

  

  As 14-3-3 theta was reported to regulate autophagy by modifying Akt phosphorylation and DDR1 inhibition failed to induce apoptosis, we reasoned that autophagy was regulated through the uncovered DDR1 and 14-3-3-Beclin-1-Akt1 complex. In clear RWJ 56110 to the current paradigm of autophagy counteract

• br Introduction Extracts of Tripterygium wilfordii

  2020-07-30

  

  Introduction Extracts of Tripterygium wilfordii Hook F (TWHF) have been used for centuries as the drug of choice for treatment of rheumatoid arthritis, a disease of autoimmune dysfunction, in traditional Chinese medicine (Bao and Dai, 2011, Tao et al., 2002). Triptolide (TP), a structurally disti

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